ABSTRACT
Introduction and Objectives: The pivotal role of chest computed tomographic (CT) to diagnosis and prognosis coronavirus disease-2019 (COVID-19) is still an open field to be explored. This study was conducted to assess the CT features in confirmed cases with COVID-19. Materials and Methods: Retrospectively, initial chest CT data of 363 confirmed cases with COVID-19 were reviewed. All subjects were stratified into three groups based on patients' clinical outcomes; non-critical group (n=194), critical group (n=65), and death group (n=104). The detailed of CT findings were collected from patients' medical records and then evaluated for each group. In addition, multinomial logistic regression was used to analyze risk factors according to CT findings in three groups of patients with COVID-19. Results: Compared with the non-critical group, mixed ground-glass opacities (GGO) and consolidation lesion, pleural effusion lesion, presence of diffuse opacity in cases, more than 2 lobes involved and opacity scores were significantly higher in the critical and death groups (P<0.05). Having more mixed GGO with consolidation, pleural effusion, lack of pure GGO, more diffuse opacity, involvement of more than 2 lobes and high opacity score identified as independent risk factors of critical and death groups. Conclusion: CT images of non-critical, critical and death groups with COVID-19 had definite characteristics. CT examination plays a vital role in managing the current COVID-19 outbreak, for early detection of COVID-19 pneumonia. In addition, initial CT findings may be useful to stratify patients, which have a potentially important utility in the current global medical situation.
ABSTRACT
COVID-19, which is caused by the SARS-Cov-2, begins with early symptoms of fever, cough, shortness of breath, myalgia, and fatigue, affecting the lungs with pneumonia and causing acute respiratory distress syndrome (ARDS). Also, the onset of the disease may with rapid progression, lead to organ dysfunction, such as acute kidney or liver damage, and even death in severe cases. Many scientific efforts are underway around the world to identify the appropriate treatment for this disease. Curcumin is a natural polyphenolic compound, which could be a potential treatment option for patients with Covid-19. In this study, we review some of the possible effects of curcumin, such as inhibiting virus entry into the cell, inhibiting virus replication and viral protease, as well as modulating some intracellular messenger pathways. To comprehensive literature review, information from an internet search of English language databases PubMed, Scopus, Web of Science and ScienceDirect as well as Persian language databases such as SID using related keywords based on MESH such as COVID-19, SARS-COV-2, Curcumin and curcuminoid between January 2020 and January 2021 were collected. This review provides some possible effects of curcumin and its mechanisms for the treatment of COVID-19.
ABSTRACT
Background and Aim: COVID-19 as a pandemic disease caused many deaths across the world and imposed considerable pressure on health care systems as well as healthcare providers. This study was conducted to clarify the elements and dimensions of experiences among nurses when caring for COVID-19 patients. Methods: This qualitative study was performed using the content analysis method in 16 nursing staffs that were responsible for caring for patients with COVID-19 selected by purposive sampling in April 2020. Deep semi-structured interviews in experimentation format was used to collect data. All interviews were recorded and typed in the MAXQDA software and then analyzed by eight steps including writing interviews, determining the semantic units, text coding, matching codes with text, categorizing and developing categories, reviewing the categories, identifying the subthemes and reporting the findings. Results: Overall, 223 codes were extracted from the interviews and after the integration of similarities three key themes including personal protection, structural protection and safety problems were obtained indicating participants' experiences on self-protection when. Conclusion: Themes such as personal protection, structural protection and safety problems are the most important concerns raised when nurses caring for COVID-19 patients and should be considered when planning to protect nursing health. © 2020 Baqiyatallah University of Medical Sciences. All rights reserved.